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2 Haemolytic disease in newborn infants Recommendations for prophylactic anti-D immunoglobulin in RhD negative women в After delivery if the infant is Rh positive в After abortion (therapeutic or spontaneous) в To cover antenatal procedures Illlustrated, chorionic villus sampling) в After threatened abortion or miscarriage в Antenatally insrt 28 and 34 weeks (not yet universal) Reasons for failure of prophylaxis в Failure of administration (commonest cause) в Inadequate dosage (routine Kleihauer tests should be performed) в Earlier sensitisation that may not be detectable at birth в Poor injection technique (should be deep intramuscular) пBox 13.

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